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Chronic Obstructive Pulmonary Disease (COPD) Patients Diagnosed With Gastro Esophageal Reflux Disease (GERD). Rates of COPD Exacerbations After Treatment With High Dose Proton Pump Inhibitor Therapy
This study is currenly Recruiting patients.
Sponsored by:
University of Florida
Purpose
The purpose of this study is to determine which COPD patients have GERD and if COPD patients
with GERD treated with high dose lansoprazole for 1 year decreases the frequency of COPD
exacerbations compared to the previous year without treatment.
Study Type: Treatment
| Condition | Treatment | Phase |
|
Gastroesophageal Reflux Chronic Obstructive Pulmonary Disease |
None | N/A |
Study Design:Time Perspective: Prospective
Official Title: COPD Patients Diagnosed With Gastro Esophageal Reflux Disease Have Decreased Rates of COPD Exacerbations After Treatment With High Dose Proton Pump Inhibitor Therapy (Esomeprazole or Lansoprazole)
Further Study Details:
Expected Total Enrollment:
Study Dates:August 2007 -
Eligibility
Ages Eligible for Study- Min: 40 Years Max: N/A
Gender: Both
Criteria
Inclusion Criteria:
diagnosis of COPD
forced expiratory volume/forced vital capacity ratio (FEV1/FVC) of < 70% on
pulmonary function testing
age > 40 years
>20 pack year history of smoking
Exclusion Criteria:
presence of the following disorders: respiratory disorders other than COPD, known
esophageal disease such as cancer, achalasia, stricture, active peptic ulcer disease,
Zollinger-Ellison syndrome, mastocytosis, scleroderma, or current abuse of alcohol
defined as greater than three alcoholic drinks per day.
Inclusion Criteria:
pulmonary function testing
Exclusion Criteria:
esophageal disease such as cancer, achalasia, stricture, active peptic ulcer disease,
Zollinger-Ellison syndrome, mastocytosis, scleroderma, or current abuse of alcohol
defined as greater than three alcoholic drinks per day.
Location and Contact Information
Please refer to this study by ClinicalTrials.gov identifier: NCT00523367
Florida
University of Florida - Jacksonville, Florida 32207
Kenneth Vega, MD 904-633-0089 kenneth.vega@jax.ufl.edu
More Information
Record Last Reviewed:June 2008
Last Updated:June 23, 2008
Record First Recieved:August 30, 2007
ClinicalTrials.gov Identifier:NCT00523367
Health Authority: United States Food and Drug Administration
Information obtained from ClinicalTrials.gov on September 08, 2010
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